EFFECT OF $ppc$ AND $dapA$ DOSAGE INCREASE ON LYSINE PRODUCTION IN $BREVIBACTER1UM~LACTOFERMENTUM$

Authors

  • N. A. Hovhannisyan Research Institute "Biotechnology", ESU, Armenia
  • M. B. Chitchyan Research Institute "Biotechnology", ESU, Armenia
  • Xie Yu Qing Xinjiang ASN (PRC)
  • G. G. Oganezova Research Institute "Biotechnology", ESU, Armenia
  • M. A. Melkumyan Research Institute "Biotechnology", ESU, Armenia
  • H. Yu. Sahakyan Research Institute "Biotechnology", ESU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2004.38.1.099

Keywords:

$Corynebacterium~glutamicum$, L-lysine, PEP carboxylase, dihydrodipicolinate, plasmid

Abstract

L-lysine production is based on the use of Corynebacterium glutamicum strains. With the cloning of the genes involved in lysine biosynthesis it is possible to investigate the influence of particular gene or group of genes on the yield of lysine. PEP carboxylase coding ppc gene and dihydrodipicolinate synthase coding dapA gene are the key genes in lysine biosynthesis. In the present work the plasmid pPPC:DAP has been constructed, containing ppc and dapA genes of Brevibacterium lactofermentum and the effect of this plasmid on lysine production increase with strain B. lactofermentum has been shown.

Downloads

Published

2003-12-28

How to Cite

Hovhannisyan, N. A., M. B. Chitchyan, Xie Yu Qing, G. G. Oganezova, M. A. Melkumyan, and H. Yu. Sahakyan. 2003. “EFFECT OF $ppc$ AND $dapA$ DOSAGE INCREASE ON LYSINE PRODUCTION IN $BREVIBACTER1UM~LACTOFERMENTUM$”. Proceedings of the YSU B: Chemical and Biological Sciences 38 (1 (203):99-104. https://doi.org/10.46991/PYSU:B/2004.38.1.099.

Issue

Vol. 38 No. 1 (203) (2004)

Section

Biology

License

Copyright (c) 2003 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.