INFLUENCE OF THE MEDULLA OBLONGATA RETICULAR NEURONS TO LOCUS COERULEUS STIMULATION IN HYPOXIA CONDITIONS

Abstract

In the oxygen deficiency conditions we studied influence of irritation of Locus Coeruleus (LC) stimulation on the impulse activity of the reticular neurons and on the respiration. Phases of hypoxia were the model of experiment. At the initial stage of hypoxia (4000-5000 m higher) the frequency of reticular neurons was growing. Against this background the facilitating influence of stimulation of LC was less prominent, though it prevailed over its inhibiting action. At the maximal altitude (7500-8000 m higher) however, the frequency of stimulus was falling, and mainly the facilitating effect of stimulation of LC was continuing. The rats after being brought back to the normal atmospheric pressure displayed gradual recovery of initial exponents with respect to both the spontaneous rhythmic activity of neurons and the reactions to stimulation. Those different reactions of irritation LC have regulation sense on respiratory neurons.