HIGH-SELECTIVE ASYMMETRIC SYNTHESIS OF $(S)$-$β$-(3-(FURAN-2-YL)-4-ALLYL-5-THIO-1,2,4-TRIAZOLE-1-YL)-$α$-ALANINE

Authors

  • H.M. Simonyan Chair of Pharmaceutical Chemistry and Pharmacognosy, Institute of Pharmacy, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2011.45.3.007

Keywords:

alanine, diastereoselective addition, Shiff’s base, dehydroalanine

Abstract

High-selective method for asymmetric synthesis of (S)-β-(3-(furan-2-yl)-4-allyl-5-thio-1,2,4-triazole-1-yl)-α-alanine through the diastereoselective addition of 4-allyi-3-thio-5-(furan-2-yl)-1,2,4-triazole to the electrophilic C=C bond of dehydroalanine in Ni(II) complex of Shiff’s base with chiral auxiliary (S)-2-N-(N'-2-chlorbenzylprolyl)aminobenzophenone was carried out. The target aminoacid with high optical purity (ee > 99%) was isolated after decomposition of the mixture of diastereomeric complexes.

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Published

2011-11-08

How to Cite

Simonyan, H.M. 2011. “HIGH-SELECTIVE ASYMMETRIC SYNTHESIS OF $(S)$-$β$-(3-(FURAN-2-YL)-4-ALLYL-5-THIO-1,2,4-TRIAZOLE-1-YL)-$α$-ALANINE”. Proceedings of the YSU B: Chemical and Biological Sciences 45 (3 (226):7-11. https://doi.org/10.46991/PYSU:B/2011.45.3.007.

Issue

Vol. 45 No. 3 (226) (2011)

Section

Chemistry

License

Copyright (c) 2011 Proceedings of the YSU

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