INTERMOLECULAR INTERACTIONS OF PYRAZOLON HYDRAZIDE WHICH REVEALS ANTIOXIDANT PROPERTY IN WATER ORGANIC MEDIUM AND THE ERYTHROCYTE π-POTENTIAL

Abstract

It has been established that there is interaction between dimethylsulfoxide (DMSO) and pirazolonhydrazide (PH), which is being revealed in the UR spectral region considering the >S=O (1053 cm^–1) and >C=O (1758 and 1720 cm^–1) groups absorptions. On the curve, which shows the dependence of PH–H₂O system electroconductivity on concentration there are two breaks, which are due to an associate formation. Densimetric measurements data is observed in the systems PH–H₂O, DMSO, physiological solution and in the temperature range 293–313 K show that only in the case of PH–physiological solution there are two minimums on the curve density-concentration, which is due to the apparent molar volume construction. The action of PH in physiological solution on the erythrocyte mass (π-potential) favors the erythrocyte layer stabilization and the preservation of the state in the system.