MITOXANTRONE INTERACTION WITH POLY(G)

Authors

  • A.T. Karapetyan Chair of Physics, YSUAC, Armenia
  • Yu.S. Babayan Chair of Physics, YSUAC, Armenia
  • M.A. Torosyan Chair of Physics, YSUAC, Armenia
  • M.A. Shahinyan Chair of Biophysics, YSU, Armenia

DOI:

https://doi.org/10.46991/PSYU:A/2015.49.3.049

Keywords:

four-stranded structure, [poly(G)]4, mitoxantrone, complex-formation, absorption spectrum, thermodynamic binding parameters

Abstract

In the present work the thermodynamic studies of mitoxantrone complexformation with four-stranded poly(G) have been carried out. The binding thermodynamic parameters, the binding constant K and the number of nucleotides corresponding to one binding site n, were determined. It was shown that mitoxantrone is bound stronger with four-stranded poly(G), then it is bound with double-stranded helix. It was also shown that due to difficulties of the intercalation of mitoxantrone molecules into four-stranded structure is bound mainly by external binding mode with [poly(G)]4 and at the interaction saturation mitoxantrone bound to much more guanines ($n\cong 10$) per one molecule. 

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Published

2015-12-15

How to Cite

Karapetyan, A., Babayan, Y., Torosyan, M., & Shahinyan, M. (2015). MITOXANTRONE INTERACTION WITH POLY(G). Proceedings of the YSU A: Physical and Mathematical Sciences, 49(3 (238), 49–54. https://doi.org/10.46991/PSYU:A/2015.49.3.049

Issue

Section

Physics