MITOXANTRONE INTERACTION WITH POLY(G)
DOI:
https://doi.org/10.46991/PSYU:A/2015.49.3.049Keywords:
four-stranded structure, [poly(G)]4, mitoxantrone, complex-formation, absorption spectrum, thermodynamic binding parametersAbstract
In the present work the thermodynamic studies of mitoxantrone complexformation with four-stranded poly(G) have been carried out. The binding thermodynamic parameters, the binding constant K and the number of nucleotides corresponding to one binding site n, were determined. It was shown that mitoxantrone is bound stronger with four-stranded poly(G), then it is bound with double-stranded helix. It was also shown that due to difficulties of the intercalation of mitoxantrone molecules into four-stranded structure is bound mainly by external binding mode with [poly(G)]4 and at the interaction saturation mitoxantrone bound to much more guanines ($n\cong 10$) per one molecule.
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