COMPARATIVE ANALYSIS OF GENOTOXIC EFFECTS OF NEW PORPHYRINS IN COMET ASSAY $IN~VIVO$

Authors

  • R. M. Haroutiounian Chair of Genetics and Cytology, YSU, Armenia
  • G. G. Hovhannisyan Chair of Genetics and Cytology, YSU, Armenia
  • R. Ye. Muradyan Chair of Genetics and Cytology, YSU, Armenia
  • K. S. Margaryan Chair of Genetics and Cytology, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2007.41.1.153

Keywords:

porphyrins TOEt4PyP, genotoxicity, Comet-assay, DNA damage

Abstract

Comparative genotoxicity of new porphyrins TOEt4PyP and their Ag-, Zn- and Co derivatives was estimated by Comet-assay in mice leukocytes in vivo, depending on time of treatment. The increase of level of DNA damage after 24 hours in comparison with 6 hours of porphyrins administration confirms their cumulative effect, that can be applied in chemotherapy of tumors.

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Published

2007-03-05

How to Cite

Haroutiounian, R. M., G. G. Hovhannisyan, R. Ye. Muradyan, and K. S. Margaryan. 2007. “COMPARATIVE ANALYSIS OF GENOTOXIC EFFECTS OF NEW PORPHYRINS IN COMET ASSAY $IN~VIVO$”. Proceedings of the YSU B: Chemical and Biological Sciences 41 (1 (212):153-55. https://doi.org/10.46991/PYSU:B/2007.41.1.153.

Issue

Vol. 41 No. 1 (212) (2007)

Section

Short Communications

License

Copyright (c) 2007 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.