SOME PECULIARITIES OF BINDING PODOPHYLLOTOXIN AND ETOPOSIDE WITH DNA OF DIFFERENT GC-CONTENT
DOI:
https://doi.org/10.46991/PYSU:B/2011.45.2.029Keywords:
guanine-cytosine content, method of thermal denaturation, podophyllotoxin, etoposide, DNAAbstract
Investigation of binding podophyllotoxin and etoposide with DNA of different guanine-cytosine content has been carried out using the method of thermal denaturation. It has been revealed, that podophyllotoxin and etoposide have a destabilizing effect on DNA. It has been shown that both compounds are preferably bound to AT-rich sites of DNA.
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Published
2011-05-11
How to Cite
Vardapetyan, H.R., A.S. Ryazanova, and A.P. Antonyan. 2011. “SOME PECULIARITIES OF BINDING PODOPHYLLOTOXIN AND ETOPOSIDE WITH DNA OF DIFFERENT GC-CONTENT”. Proceedings of the YSU B: Chemical and Biological Sciences 45 (2 (225):29-33. https://doi.org/10.46991/PYSU:B/2011.45.2.029.
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Biology
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