BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV

Authors

  • N.M. Movsisyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • S.G. Sharoyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • A.A. Antonyan H.Ch. Buniatian Institute of Biochemistry, NAS RA
  • S.S. Mardanyan H.Ch. Buniatian Institute of Biochemistry, NAS RA

DOI:

https://doi.org/10.46991/PYSU:B/2013.47.1.036

Keywords:

amyloid beta peptides, dipeptidyl peptidase IV, fibril formation, Proline Rich Peptide 4, enzymatic cleavage of Aβ peptides

Abstract

It is shown that the amyloid beta peptides Aβ(1-16) and Aβ(1-40) and a cytokine from neurosecretory granules of bovine neurohypophysis, Proline Rich Peptide PRP-4, are truncated at the presence of multifunctional dipeptidyl peptidase IV (CD26/DPPIV), widely expressed in different mammalian tissues. It means that these neuropeptides represent substrates of the enzyme. Besides, it appeared that at the presence of CD26/DPPIV the process of Aβ(1-40) aggregation in vitro was hindered. 

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Published

2013-03-10

How to Cite

Movsisyan, N.M., S.G. Sharoyan, A.A. Antonyan, and S.S. Mardanyan. 2013. “BREAKDOWN OF SOME NEURONAL PEPTIDES WITH DIPEPTIDYL PEPTIDASE IV”. Proceedings of the YSU B: Chemical and Biological Sciences 47 (1 (230):36-39. https://doi.org/10.46991/PYSU:B/2013.47.1.036.

Issue

Vol. 47 No. 1 (230) (2013)

Section

Biology

License

Copyright (c) 2013 Proceedings of the YSU

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