THE PECULIARITIES OF COMPLEXATION OF DNA MACROMOLECULE WITH LOW MOLECULAR LIGANDS

S. G. Haroutiunian; V. I. Vardanyan; Y. B. Dalyan

doi:10.46991/PYSU:A/2004.38.3.003

THE PECULIARITIES OF COMPLEXATION OF DNA MACROMOLECULE WITH LOW MOLECULAR LIGANDS

Authors

S. G. Haroutiunian Chair of Molecular Physics, YSU, Armenia
V. I. Vardanyan Chair of Molecular Physics, YSU, Armenia
Y. B. Dalyan Chair of Molecular Physics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:A/2004.38.3.003

Keywords:

DNA complexation , reversibly and irreversibly binding ligands, Pt(II) and Ru(III) complexes

Abstract

The present review is devoted to the analysis of peculiarities of DNA complexation with reversibly and irreversibly binding ligands. Three classes of low molecular ligands with different types of binding were discussed. These types of ligands particularly are: bivalent transitional metal ions, porphyrin complexes, and zwitterionic amino acids. As irreversible binding ligands some Pt(II) and Ru(III) complexes were used. The systematization of the general patterns and revealing of specific differences in interaction of above mentioned ligands with double helix DNA is presented.

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Published

2004-10-19

How to Cite

Haroutiunian, S. G., Vardanyan, V. I., & Dalyan, Y. B. (2004). THE PECULIARITIES OF COMPLEXATION OF DNA MACROMOLECULE WITH LOW MOLECULAR LIGANDS. Proceedings of the YSU A: Physical and Mathematical Sciences, 38(3 (205), 3–34. https://doi.org/10.46991/PYSU:A/2004.38.3.003