DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA

Authors

  • S.N. Hakobyan State Engineering University, Armenia

DOI:

https://doi.org/10.46991/PYSU:B/2016.50.2.051

Keywords:

DNA, ethidium bromide, mitoxantrone, complex-formation, thermodynamic parameters

Abstract

The value of binding enthalpy change (ΔH) due to DNA–ligand complexformation has been determined by Van’t–Hoff mode having dependence of binding constant (K) on the reverse value of absolute temperature. Calculations that were carried out for DNA–ethidium bromide and DNA–mitoxantrone complexes showed, that if ΔH is determined from the values of K at two different temperatures, the calculated value of ΔH in the error frame coincides with its experimental value.

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Published

2016-07-01

How to Cite

Hakobyan, S.N. 2016. “DETERMINATION OF BINDING ENTHALPY VALUE AT COMPLEX-FORMATION OF LIGAND WITH DNA”. Proceedings of the YSU B: Chemical and Biological Sciences 50 (2 (240):51-54. https://doi.org/10.46991/PYSU:B/2016.50.2.051.

Issue

Vol. 50 No. 2 (240) (2016)

Section

Biology

License

Copyright (c) 2016 Proceedings of the YSU

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.