THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH

Authors

  • S. A. A. Sulyman Mosul University, Irak, Chair of the Molecular Physics, YSU, Armenia
  • A. A. Ghazaryan Chair of Molecular Physics, YSU, Armenia
  • Ye. B. Dalyan Chair of Molecular Physics, YSU, Armenia

DOI:

https://doi.org/10.46991/PYSU:A/2009.43.2.055

Keywords:

DNA, porphyrin, ionic strength

Abstract

UV-VIS spectrophotometry and circular dichroism (CD) methods were applied to study the binding of DNA with three novel Ag-containing porphyrins meso-tetra(4N-allylpyridyl) (AgTAlPyP4), meso-tetra(4N-butylpyridyl) (AgTButPyP4) and meso-tetra(4N-oxyethylpyridyl) (AgTOEtPyP4) at high ionic strength. The binding constant Kb and stoichiometry n were determined from binding isotherms for each ligand–DNA complex. The Gibbs free energy, enthalpy and entropy of binding also were calculated using the values of Kb . Obtained results show that these porphyrins associate with the duplex DNA via outside binding mode.

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Published

2009-06-26

How to Cite

Sulyman, S. A. A., Ghazaryan, A. A., & Dalyan, Y. B. (2009). THE INTERACTION OF Ag-CONTAINING PORPHYRINS WITH DNA AT HIGH IONIC STRENGTH. Proceedings of the YSU A: Physical and Mathematical Sciences, 43(2 (219), 55–59. https://doi.org/10.46991/PYSU:A/2009.43.2.055

Issue

Section

Physics