BINDING PECULIARITIES OF POLY(rA)-POLY(rU) WITH MINOR GROOVE LIGAND HOECHST 33258
DOI:
https://doi.org/10.46991/PYSU:B/2021.55.2.144Keywords:
synthetic polynucleotide, intercalator, minor groove binder, absorption spectra, fluorescence spectraAbstract
Study on the interaction of DNA-specific ligands – classical intercalator acridine orange (AO) and groove binding compound Hoechst 33258 (H33258) with poly(rA)-poly(rU), being a model for double-stranded (ds-) RNA, has been carried out. The absorption and fluorescence spectra of the complexes of these ligands with ds-polynucleotide were obtained. It was revealed that the optic and fluorescent characteristics of the complexes of both ligands with ds-RNA are similar with those at the complex-formation with DNA.
Downloads
Published
2021-08-30
How to Cite
Parsadanyan, Marine A., Mariam A. Shahinyan, Zvart H. Movsisyan, and Ara P. Antonyan. 2021. “BINDING PECULIARITIES OF POLY(rA)-POLY(rU) WITH MINOR GROOVE LIGAND HOECHST 33258”. Proceedings of the YSU B: Chemical and Biological Sciences 55 (2 (255):144-50. https://doi.org/10.46991/PYSU:B/2021.55.2.144.
Issue
Section
Biology
License
Copyright (c) 2021 Proceedings of the YSU
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.